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KMID : 0356620150300040488
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Journal of Korean Society of Endocrinology
2015 Volume.30 No. 4 p.488 ~ p.493
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Subclinical Atherosclerosis in Patients with Cushing Syndrome: Evaluation with Carotid Intima-Media Thickness and Ankle-Brachial Index
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:Petramala Luigi
:Lorenzo D’Elia/:Iannucci Gino/:Concistre Antonio/:Zinnamosca Laura/:Marinelli Cristiano/:Vincentis Giuseppe De/:Ciardi Antonio/:Toma Giorgio De/:Letizia Claudio
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Abstract
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Background : Cushing syndrome (CS) has been described as a killing disease due its cardiovascular complications. In fact, chronic cortisol excess leads to a constellation of complications, including hypertension, hyperglycemia, adiposity, and thromboembolism. The main vascular alteration associated with CS is atherosclerosis.
Methods : Aim of this study was to analyze carotid intima-media thickness (cIMT) and ankle-brachial index (ABI), two surrogate markers of subclinical atherosclerosis in a consecutive series of CS patients, compared to patients with essential hypertension (EH) and health subjects (HS).
Results : Patients with CS showed a significant increase (P<0.05) of cIMT (0.89±0.17 mm) compared to EH (0.81±0.16 mm) and HS (0.75±0.4 mm), with a high prevalence of plaque (23%; P<0.03). Moreover, CS patients showed a mean ABI values (1.07±0.02) significantly lower respect to HS (1.12±0.11; P<0.05), and a higher percentage (20%) of pathological values of ABI (≤0.9; P<0.03).
Conclusion : In conclusion, we confirmed and extended the data of cIMT in CS, and showed that the ABI represent another surrogate marker of subclinical atherosclerosis in this disease.
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KEYWORD
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Cushing syndrome, Subclinical atherosclerosis, Carotid intima-media thickness, Ankle brachial index
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